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M94A2951.TXT
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1994-10-25
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Document 2951
DOCN M94A2951
TI Chronic bacterial enteropathy in AIDS.
DT 9412
AU Giang TT; Kotler DP; Orenstein JM; St. Luke's/Roosevelt Hosp. Ctr., New
York, NY 10025.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):188 (abstract no. PB0180). Unique
Identifier : AIDSLINE ICA10/94369624
AB OBJECTIVE: To determine the prevalence and clinical correlations of
adherent bacteria in intestinal biopsies. METHODS: Biopsies from 66
HIV-infected individuals undergoing endoscopy in 1991 were reviewed
blindly. Light and electron microscopic detection of adherent bacteria,
their localization in the intestine, and the relationships to diarrhea,
weight loss, PBL CD4+ count, D-xylose absorption, travel history, and
antibiotic usage were determined. RESULTS: Adherent bacteria were seen
in 11 of 66 people, and in no controls. The major localization was in
the right colon. Three distinct morphologic patterns of bacterial
adherence were observed. Patients harboring adherent bacteria were more
likely to have diarrhea, weight loss (p < 0.005), and PBL CD4+ counts
less than 100 (p < 0.05). D xylose malabsorption was found in 70%. There
were no associations with foreign or domestic travel, or with antibiotic
usage. Antibiotic therapy, produced symptomatic improvement in most
patients, but did not change xylose absorption. CONCLUSION: Chronic
intestinal infection with adherent bacteria may produce a clinical
syndrome of AIDS-associated diarrhea and wasting.
DE Acquired Immunodeficiency Syndrome/*PATHOLOGY AIDS-Related
Opportunistic Infections/*PATHOLOGY Bacterial Adhesion/PHYSIOLOGY
Bacterial Infections/*PATHOLOGY Chronic Disease Colitis/PATHOLOGY
Diarrhea/*PATHOLOGY Enteritis/*PATHOLOGY Human Intestinal
Mucosa/PATHOLOGY Microscopy, Electron MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).